糖心原创出品

Dr. Emil Jovanov with the smart water bottle he invented. Dr. Jovanov is a coauthor of a paper that explores using mHealth technologies to battle COVID-19.

Michael Mercier | UAH

Support for telehealth and mobile health monitoring has risen among healthcare workers and consumers since the rise of the COVID-19 pandemic, according to .

Dr. Emil Jovanov, a pioneer in the wearable health monitoring field from 糖心原创出品 (UAH), participated and was a coauthor of the study conducted by a task force of experts organized by the Mass General Brigham (MGB) Center for COVID Innovation.

鈥淎ccording to our interviews with healthcare professionals, we found out that the support for telemedicine and tele-rehabilitation increased from about 10% before the pandemic to almost 60% now,鈥� says Dr. Jovanov, an associate professor of electrical and computer engineering who was selected as an Institute of Electrical and Electronics Engineers (IEEE) fellow in 2020 for his contributions to the field of wearable health monitoring.

鈥淭hat can create a significant change in digital healthcare that would otherwise take decades,鈥� Dr. Jovanov says.

According to the study, mobile health technologies (mHealth) create tremendous opportunities for monitoring, mitigation and testing in the COVID-19 pandemic and future pandemics.

Dr. Jovanov says the nation鈥檚 COVID battle could be assisted by an integrated mHealth system that can help assess who needs to be tested by providing relevant information through contact tracing, tracing of shared space and infrastructure, and monitoring of physiological changes.

鈥淎ll this information can be used to inform decisions and optimize the use of resources,鈥� he says. 鈥淎n integrated system can also characterize disease spread by tracking spatio-temporal patterns of new cases.鈥�

Dr. Jovanov joined experts from top bioengineering institutions across the globe for the three-month effort organized by lead author Dr. Paolo Bonato, an associate professor in the Department of Physical Medicine and Rehabilitation at Harvard Medical School, and Dr. Bonato鈥檚 team at the Motion Analysis Laboratory, which he directs. The laboratory is located at Spaulding Rehabilitation Hospital in Boston, a member of the Mass General Brigham Integrated Health System.

鈥淭he task force was assembled by recruiting experts in electronic patient-reported outcomes (ePRO), wearable sensors and digital contact tracing technologies to review and explore the use of mobile health technologies to monitor and mitigate the effects of the COVID-19 pandemic,鈥� he says.

鈥淲e identified technologies that could be deployed in response to the COVID-19 pandemic to predict symptom escalation for earlier intervention, to monitor individuals who are presumed non-infected and to enable prediction of exposure to SARS-CoV-2.鈥�

鈥淲earable monitoring has tremendous potential, particularly in extraordinary circumstances such as the current pandemic,鈥� says Dr. Jovanov, who in 2000 was first to propose and was the 2014 Alabama Inventor of the Year for a smart pill bottle he developed that鈥檚 licensed to the company AdhereTech and used by thousands of patients.

鈥淎 combination of off-the-shelf ubiquitous technology already in use, such as smartphones, smartwatches and wearable sensors, new advanced sensors and the integration of mobile health systems could better prepare us for dealing with the challenges of future surges of COVID-19 cases and to minimize the effects of future pandemics on routine clinical services,鈥� he says.

The devices could provide early warning of onset, detect health deterioration that requires hospitalization, offer automatic triage and large-scale monitoring in improvised hospitals, and monitor patients after they are discharged to ensure continuity of clinical care services, says Dr. Jovanov. With Dr. Aleksandar Milenkovic, 15 years ago he implemented the first low-power wearable wireless body monitor in cooperation with Mayo Clinic to introduce the era of mobile health.

鈥淥ur task force summarized some of the opportunities that most of health professionals are not even aware of,鈥� he says.

鈥淲e currently have more than 60 million wearable device users in U.S., more than double the users of five years ago. Last year, 20 million new smartwatches were sold. Device intelligence and ubiquitous connectivity create tremendous healthcare opportunities, as outlined in our paper.鈥�

Home monitoring applications could be augmented with self-reporting of symptoms, a system that can be implemented at much bigger scale, Dr. Jovanov says.

鈥淎s a result, we can avoid unnecessary visits for people with some other conditions, like colds, who otherwise would come to see their physician and risk additional possible exposures to SARS-CoV-2,鈥� he says.

鈥淭eleconferencing in combination with monitoring of physiological signals and history of changes of physiological status would provide more effective help at home, without the need to take trips to physicians or hospitals.鈥�

Personal monitors can detect COVID warning signs at very early stages, he says.

鈥淲earable monitors can also monitor heart activity and changes in the autonomous nervous system,鈥� says Dr. Jovanov, who demonstrated the wearable wireless remote heart monitor in a personal area network 20 years ago at UAH.

鈥淓ven before the patient feels short of breath, it has been noted that they may experience desaturation which could be easily identified and monitored through an oximeter inside a healthcare facility, as well as in the home setting.鈥�

In addition to the onset of COVID, wearable monitors can also track the recovery of patients at home and detect delayed cardiovascular and circulatory system problems caused by exposure.

鈥淢ost people have a long recovery from COVID-19, particularly in the case of other comorbidities,鈥� Dr. Jovanov says. 鈥淔ollowing trends of recovery, or even deterioration of a user鈥檚 state, the system can certainly raise the flag in real-time if the recovery is not going as expected or if the user鈥檚 state turns worse at home after release from hospital.鈥�

In addition, monitoring systems would provide physicians with a record of recent health changes, instead of the snapshot of the patient鈥檚 current state that an examination provides.

Another very important application is monitoring of frontline healthcare workers, a very vulnerable population exposed to the virus daily, for possible infections or burnout.

Since wearable devices can detect other wireless devices around them, tracking of users and contacts can be automated.

鈥淔or example, an intelligent visitor鈥檚 badge can detect all the places a person visited and their contacts with other people,鈥� Dr. Jovanov says. 鈥淚f it turns out that the visitor was sick at the time of the visit, you can implement additional cleaning of places and testing of people that person was in contact with.鈥�

Google and Apple are currently working to enable the use of Bluetooth technology to help governments and health agencies reduce the spread of the virus while maintaining user security and privacy.

鈥淭he main implementation barriers are related to privacy, not the technological issues,鈥� Dr. Jovanov says. 鈥淲e describe both systems and applications in our paper.鈥�

In fact, most of the factors limiting applications of mHealth technology are not technology related, Dr. Jovanov says.

鈥淭here are many issues, ranging from Food and Drug Administration approval of novel sensors and applications to privacy concerns and even liability issues,鈥� he says. 鈥淭hose are not easy problems to solve because of the deep-rooted perceptions and possible misuse of technology.鈥�

Because they are scalable and can be deployed in spaces with no infrastructure in a very short period, wearable health monitoring systems present an opportunity for field hospitals that may become necessary in pandemic outbreaks, Dr. Jovanov says. The same technology and system can be applied to different disaster scenarios.

As part of the research, the task force prepared a web-based questionnaire to assess requirements for contact tracing in hospitals and asked faculty at UAH鈥檚 College of Nursing and Department of Electrical and Computer Engineering to provide feedback independent of the current technological capabilities.

鈥淲e truly appreciate the timely feedback we received from our UAH colleagues,鈥� Dr. Jovanov says.

鈥淲e believe that papers like this one can raise the awareness of the medical and technical communities and create truly multidisciplinary collaborations to implement new applications and develop new technologies,鈥� Dr. Jovanov says.

鈥淢assive deployment of mHealth systems provides the big data necessary to apply artificial intelligence methods to a fundamental understanding of underlying conditions, better and more accurate methodologies, personalized healthcare and more efficient mitigation of the effects of pandemics.鈥�